The affliction on Carl that generates the Post Nut Clarity blackout whenever he uses Daughter's Kiss.
Carl identifies the Post Nut Clarity debuff as coming from his soul poisoning, which knocks him unconscious once he activates Daughter's Kiss.
He judges it dangerous as hell: twenty-five seconds of helplessness in the middle of a battle. His workaround is procedural rather than curative—he resolves to make certain he only uses the skill from a position where the debuff going off won't kill him. It's a cost he now has to build his tactics around.
The underlying condition that makes Carl's strongest attack a liability.